21 September 2019

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Science
6 Sep  2019 128

Blood cell management made possible

Scientists from the National Research Nuclear University MEPhI (NRNU MEPhI) and the University of Oulu (Finland) conducted joint studies to study the interaction of red blood cells controlled from the outside with optical laser tweezers.

 

Thanks to the results, researchers can significantly advance in the development of methods for targeted delivery of drugs, in immunotherapy and even the creation of artificial blood. The results of the study are published in the scientific journal "Scientific Reports".

Scientists are actively researching blood cells in order to use them as a “natural” transport for drugs. If successful, the developed method will allow the transit of drugs placed on the surface of red blood cells directly in the area of ​​biological tissues affected by the disease.

This idea claims the role of the latest paradigm in medicine. However, for practical implementation of the method, scientists lack research on the effect of nanoparticles that are part of drugs, and the question arises of the behavior of red blood cells when interacting with drugs and how it will affect a person.

Igor Meglinsky, professor at NRNU MEPhI and the University of Oulu, told the method by which the cells are manipulated: “We used, in particular, optical laser tweezers (the method awarded the Nobel Prize in 2018), as well as phase and electron microscopy. Optical laser tweezers allows you to create conditions for the interaction of blood cells that cannot be observed under ordinary conditions. The combination of methods makes it possible to measure the effect of certain nanoparticles on the interaction of red blood cells. "

In the near future, scientists, in addition to improving technology, plan to significantly expand the range of tasks.

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